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2. Enantiomers in Medicine
About this Lecture
In the second mini-lecture, we look at some real-world examples of where enantiomers are found in medicine, and how their existence is accounted for in synthesis. Then we dive into the specifics of why chirality causes a difference in biological function. Then, we take a look at some more commonplace examples of chirality in medicine, ibuprofen, herbicides, and thalidomide, one of the most famous and devastating cases of chirality. To finish off, we learn about optical activity, what this means and some initial steps to understanding how this helps to distinguish and name enantiomers.
In this course, Professor David Bergbreiter (Texas A&M) introduces us to the concept of optical isomerism, the idea that certain molecules have mirror images of themselves which are non-superimposable, giving rise to a completely new set of properties. We begin by: (i) first looking at the concept of isomers, where optical isomers can be found and an initial concept of non-superimposability, then; (ii) talking about where optical isomers (or enantiomers) can be found in medicine and introducing optical activity; (iii) and then moving on to develop the idea of optical activity, and how we use that to name and identify different enantiomers, using various different examples; (iv) then briefly touching on other nomenclature and representations; (v) and finally using this new nomenclature we have learned on a more advanced level with real molecule.
Professor David Bergbreiter obtained his B.S from Michigan State and his PhD from MIT. He has worked as an academic in various places but he currently works at Texas A&M, receiving awards for his research and teaching at the university, including the South Eastern Conference Faculty Achievement Award (2017), the Regents' Professor Award (2016 – present), among many others. David Bergbreiter and his group explore new chemistry related to catalysis and polymer functionalization using the tools and precepts of synthetic organic chemistry to prepare functional oligomers or polymers that in turn are used to either affect catalysis in a greener, more environmentally benign way or to efficiently functionalize polymers. Often this involves developing new separation chemistry that creatively uses polymers but retains the reactivity of a low molecular weight catalyst, ligand, or reagent. These green chemistry projects involve fundamental research both in synthesis and catalysis but still have relevance to practical problems.
Cite this Lecture
Bergbreiter, D. (2022, January 18). Optical Isomerism - Enantiomers in Medicine [Video]. MASSOLIT. https://massolit.io/courses/optical-isomerism/enantiomers-in-medicine
Bergbreiter, D. "Optical Isomerism – Enantiomers in Medicine." MASSOLIT, uploaded by MASSOLIT, 18 Jan 2022, https://massolit.io/courses/optical-isomerism/enantiomers-in-medicine