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2. Regions of ¹H/¹³C NMR Spectra
About this Lecture
In the second mini-lecture, we investigate the effect of electron shielding on a nucleus we are analysing by NMR spectroscopy. Neighbouring electron-donating and electron-withdrawing groups have shielding and de-shielding effects respectively, removing electron density around a nucleus. How does this affect its interaction with the applied magnetic field? Nuclear magnetic resonance is measured by chemical shift, so how does shielding and de-shielding affect chemical shift? We learn that certain functional have predictable chemical shifts, meaning that we can begin to identify certain peaks if we know their chemical shift.
In this course, Dr Danny Allwood (Sheffield Hallam University) introduces the concept of NMR spectroscopy, a ubiquitous analytical tool used in all fields of chemistry to determine the structure of compounds. We start by: (i) investigating two types of NMR based on certain nuclei, 1H and 13C, and the sorts of information we can gather from NMR spectra of these nuclei; then (ii) learning about the different regions of a given NMR spectrum, understanding that certain environments and functional groups are likely to be found to be within a defined region of chemical space; (iii) and then beginning to understand why this happens; before (iv) moving onto the concept of integration, specifically with 1H spectra; and then (v) understanding how nuclei in adjacent environments affect each other’s peaks on a spectrum by a process known as coupling; before finally (vi) showing the NMR spectra of isomers, and realising their differences and understanding why this happens.
Dr Danny Allwood joined Sheffield Hallam University from the University of Cambridge, where he undertook a PhD (2008-2012) and post-doctoral research (2012-2015) with Professor Steven V. Ley CBE FRS. Prior to this, he attained my undergraduate degree at the University of Warwick (2004-2008). His current research programme is focused on the development of practical synthetic and catalytic organic transformations.
Cite this Lecture
Allwood, D. (2022, January 12). NMR Spectroscopy - Regions of ¹H/¹³C NMR Spectra [Video]. MASSOLIT. https://massolit.io/courses/nmr-spectroscopy/regions-of-h-c-nmr-spectra
Allwood, Danny. "NMR Spectroscopy – Regions of ¹H/¹³C NMR Spectra." MASSOLIT, uploaded by MASSOLIT, 12 Jan 2022, https://massolit.io/courses/nmr-spectroscopy/regions-of-h-c-nmr-spectra